Adult 1st dose: 3.7 mg/m
2 once every 7 days. 2nd dose: 5.5 mg/m
2 once every 7 days. 3rd dose: 7.4 mg/m
2 once every 7 days. 4th dose: 9.25 mg/m
2 once every 7 days. 5th dose: 11.1 mg/m
2 once every 7 days. Increased dosage may be continued but must not exceed 18.5 mg/m
2 once every 7 days.
Childn 1st dose: 2.5 mg/m
2 once every 7 days. 2nd dose: 3.75 mg/m
2 once every 7 days. 3rd dose: 5 mg/m
2 once every 7 days. 4th dose: 6.25 mg/m
2 once every 7 days. 5th dose: 7.5 mg/m
2 once every 7 days. Increased dosage may be continued but must not exceed 12.5 mg/m
2 once every 7 days. Discontinue dosage increase for adult & childn after dose which reduces white cell count to approx 3 x 10
9/L (3,000/mm
3).
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